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流行病与卫生统计学

流行病与卫生统计学

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褚敏捷

日期：2021-03-10 访问次数：5682次


    褚敏捷，教授，博士生导师。威尼斯欢乐娱人v675副院长（主持）、流行病与卫生统计学系主任。江苏省青年科技人才“托举工程”培养对象，江苏高校“青蓝工程”优秀青年骨干教师培养对象，南通市“江海英才”培养对象。主要从事肺癌、肺纤维化等肺部疾病遗传易感性及生物标志物研究。主持国家重点研发计划子任务、国家自然科学基金面上项目和青年项目、江苏省自然科学基金面上项目及江苏省高校自然科学研究面上项目等多项课题。在国内外学术期刊发表高水平论文60余篇，其中高被引论文1篇，以第一或通讯作者在Human Molecular Genetics，Archives of Toxicology，Respirology等期刊发表论文40篇，中华系列论文多篇，参与工作发表在Nature Genetics，Clinical Cancer Research等重要期刊上，论文总引用累计超2600次，个人H指数25。获江苏省医学新技术引进一等奖及江苏省高等学校科学技术研究成果奖三等奖各一项。获国家发明专利两项。现担任中国医疗保健国际交流促进会公共卫生与预防医学分会委员、江苏省预防医学会流行病学分会常务委员、中国抗癌协会肿瘤流行病学专业委员会委员等职。指导学生获“挑战杯”全国大学生课外学术科技作品竞赛国赛三等奖及省赛一等奖，指导学生获江苏省优秀本科毕业论文二等奖、三等奖各1项。


招生方向：流行病与卫生统计学


代表论文：

  1. Chu M*, Wu S*, Wang W, Mao L, Yu Y, Jiang L, Yuan W, Zhang M, Sang L, Huang Q, Tian T, Han L, Zhuang X, Zhang ZF, Wu J#. MiRNA-sequencing Reveals miRNA-4508 from Peripheral Blood Lymphocytes as Potential Diagnostic Biomarker for Silica-related Pulmonary Fibrosis: A Multistage Study. Respirology. 2020;25(5):511-517

  2. Chu M*, Wu S*, Wang W*, Yu Y*, Zhang M, Sang L, Tian T, Lu Y, Yuan W, Huang Q, Yi M, Gao Y, Xiao J, Lian Y, Zhuang X, Zhang ZF#, Wu J#.Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study.Occup Environ Med. 2019;76(3):169-174

  3. Yu Y*, Mao L*, Lu X*, Yuan W, Chen Y, Jiang L, Ding L, Sang L, Xu Z, Tian T, Wu S#, Zhuang X#, Chu M#. Functional Variant in 3'UTR of FAM13A Is Potentially Associated with Susceptibility and Survival of Lung Squamous Carcinoma.DNA Cell Biol. 2019;38(11):1269-1277

  4. Wang W*, Yu Y*, Xiao J, Gao Y, Sang L, Lian Y, Lu Y, Tian T, Zhuang X, Han L, Chu M#. A Novel Variant of Desmoplakin Is Potentially Associated with Silicosis Risk.DNA Cell Biol. 2018;37(11):925-931

  5. Wang W*, Yu Y*, Wu S*, Sang L, Wang X, Qiu A, Yu X, Li J, Zhang L, Yi M, Zheng H, Gao Y, Xiao J, Lu Y, Jiang L, Lian Y, Zhuang X#, Tian T#, Chu M#. The rs2609255 polymorphism in the FAM13A gene is reproducibly associated with silicosis susceptibility in a Chinese population.Gene. 2018 Jun 30;661:196-201

  6. Zhu X*, Wu D*, Sang L, Wang Y, Shen Y, Zhuang X, Chu M#, Jiang L#. Comparative effectiveness of glucosamine, chondroitin, acetaminophen or celecoxib for the treatment of knee and/or hip osteoarthritis: a network meta-analysis. Clin Exp Rheumatol. 2018 Jul-Aug;36(4):595-602

  7. Xiao J*, Chu M*, Shen H*, Ren W, Li Z, Hua T, Xu H, Liang Y, Gao Y#, Zhuang X#. Relationship of "weekend warrior" and regular physical activity patterns with metabolic syndrome and its associated diseases among Chinese rural adults.J Sports Sci. 2018 Jan 18:1-9

  8. Wu S*, Mao L*, Li Y, Yin Y, Yuan W, Chen Y, Ren W, Lu X, Li Y, Chen L, Chen B, Xu W, Tian T, Lu Y, Jiang L, Zhuang X, Chu M#, Wu J#. RAGE may act as a tumour suppressor to regulate lung cancer development.Gene. 2018 Apr 20;651:86-93  

  9. Peng P, Su S, Fairley CK, Chu M, Jiang S, Zhuang X, Zhang L. A Global Estimate of the Acceptability of Pre-exposure Prophylaxis for HIV Among Men Who have Sex with Men: A Systematic Review and Meta-analysis.AIDS Behav. 2018 Apr;22(4):1063-1074

  10. Yang Y, Zhao XP, Zou HC, Chu MJ, Zhong P, Li XS, Li XY, Yu YH, Zhu KX, Chen YJ, Xia F, Zhu BW, Ruan LQ, Bao YN, Zhuang X. Phylogenetic and temporal dynamics of human immunodeficiency virus type 1 CRF01_AE and CRF07_BC among recently infected antiretroviral therapy-naïve men who have sex with men in Jiangsu province, China, 2012 to 2015: A molecular epidemiology-based study.Medicine (Baltimore). 2018 Feb;97(6):e9826

  11. Chu M*, Zhu X*, Wang C, Rong J, Wang Y, Wang S, Xing B, Tao Y, Zhuang X, Jiang L#. The rs4238326 polymorphism in ALDh2A2 gene potentially associated with non-post traumatic knee osteoarthritis susceptibility: a two-stage population-based study. Osteoarthritis Cartilage. 2017;25(7):1062-1067

  12. Chu M*, Zhang W*, Zhang X, Jiang W, Huan X, Meng X, Zhu B, Ynag Y, Tao Y,Tian T, Lu Y, Jiang L, Zhang L, Zhuang X#.HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China. Sci Rep. 2017 May 8;7(1):1570

  13. Wu S*, Yuan W*, Shen Y*, Lu X, Li Y, Tian T, Jiang L, Zhuang X#, Wu J#, Chu M#.The miR-608 rs4919510 polymorphism may modify cancer susceptibility based on type. Tumour Biol. 2017;39(6):1010428317703819

  14. Yu Y*, Tao Y*, Liu L*, Yang J, Wang L, Li X, Zhuang X, Chu M#.New concept of the Axin2 rs2240308 polymorphism and cancer risk: an updated meta-analysis. Neoplasma. 2017; 64(2):269-277

  15. Xian Y, Zhu B, Zhang X, Ma P, Wei Y, Xia H, Jiang W, Yang C, Meng X, Peng P, Yang Y, Jiang L, Chu M, Zhuang X. Risk factors associated with sexually transmitted infections among HIV infected men who have sex with men.PLoS One. 2017 Feb 3;12(2):e0170635

  16. Chu M*,#, Yuan W*, Wu S*, Wang Z*, Mao L, Tian T, Lu Y, Zhu B, Yang Y, Wang B, Gao H, Jiang L, Zhuang X. Quantitative Assessment of Polymorphisms in h29 lncRNA and Cancer Risk: A Meta-analysis of 13,392 Cases and 18,893 Controls. Oncotarget. 2016;7(48):78631-78639

  17. Chu M*, Rong J, Wang Y, Zhu L, Xing B, Tao Y, Zhuang X, Zhao Y, Jiang L#. Strong association of the polymorphisms in PBEF1 and knee OA risk: a two-stage population-based study in China.Sci Rep. 2016 11;6:19094.

  18. Tian T*, Li C*, Xiao J, Shen Y, Lu Y, Jiang L, Zhuang X, Chu M#. Quantitative Assessment of the Polymorphisms in the HOTAIR lncRNA and Cancer Risk: A Meta-Analysis of 8 Case-Control Studies.PLoS One. 2016;11(3):e0152296

  19. Li T*, Xian Y, Tian T, Zhuang X,Chu M#. New evidence of TERT rs2736098 polymorphism and cancer risk: an updated meta-analysis. JBUON. 2016; 21(2): 491-497

  20. Wang Y*, Chu M, Rong J, Xing B, Zhu L, Zhao Y, Zhuang X, Jiang L#. No association of the single nucleotide polymorphism rs8044769 in the fat mass and obesity-associated gene with knee osteoarthritis risk and body mass index: A population-based study in China.Bone Joint Res. 2016;5(5):169-74

  21. Jiang L, Xie X, Wang Y, Wang Y, Lu Y, Tian T, Chu M, Shen Y. Body mass index and hand osteoarthritis susceptibility: an updated meta-analysis.Int J Rheum Dis. 2016 Dec;19(12):1244-1254

  22. Wang Y, Xie X, Zhu X, Chu M, Lu Y, Tian T, Zhuang X, Jiang L. Fire-Needle Moxibustion for the Treatment of Knee Osteoarthritis: A Meta-Analysis.Evid Based Complement Alternat Med. 2016;2016:1392627

  23. Xiao J, Shen C, Chu MJ, Gao YX, Xu GF, Huang JP, Xu QQ, Cai H. Physical Activity and Sedentary Behavior Associated with Components of Metabolic Syndrome among People in Rural China.PLoS One. 2016 Jan 20;11(1):e0147062

  24. Chu M*, Sun C*, Chen W*, Jin G, Gong J, Zhu M, Yuan J, Dai J, Wang M, Pan Y, Song Y, Ding X, Guo X, Du M, Xia Y, Kan H, Zhang Z, Hu Z#, Wu T#, Shen H#.Personal exposure to PM2.5, genetic variants and DNA damage: a multi-center population-based study in Chinese. Toxicol Lett. 2015 Jun 15;235(3):172-8

  25.  Sun C*, Chu M*, Chen W*, Jin G, Gong J, Zhu M, Yuan J, Dai J, Wang M, Pan Y, Song Y, Ding X, Du M, Zhang Z, Hu Z#, Wu T#, Shen H#. Genetic variants of H2AX gene were associated with PM2.5- modulated DNA damage levels in Chinese Han populations. Mutat Res. 2015 Aug;778:41-5

  26. Wang T, Yang J, Ji X, Chu M, Zhang R, Dai J, Jin G, Hu Z, Shen H, Ni C. Pathway analysis for a genome-wide association study of pneumoconiosis.Toxicol Lett. 2015 Jan 5;232(1):284-92

  27. Chu M*, Ji X*, Chen W*, Zhang R*, Sun C, Wang T, Luo C, Gong J, Zhu M, Fan J, Hou Z, Dai J, Jin G, Wu T, Chen F, Hu Z#, Ni C#, Shen H#. A genome-wide association study identifies susceptibility loci of silica related pneumoconiosis in Han Chinese. Hum Mol Genet. 2014 Dec 1;23(23):6385-94

  28. Chu M*, Zhang R*, Zhao Y*, Wu C, Guo H, Zhou B, Lu J, Shi Y, Dai J, Jin G, Ma H, Dong J, Wei Y, Wang C, Gong J, Sun C, Zhu M, Qiu Y, Wu T, Hu Z, Lin D, Shen H, Chen F#. A genome-wide gene-gene interaction analysis identifies an epistatic gene pair for lung cancer susceptibility in Han Chinese.Carcinogenesis. 2014 Mar;35(3):572-7.

  29. Zhang R*, Chu M*, Zhao Y*, Wu C, Guo H, Shi Y, Dai J, Wei Y, Jin G, Ma H, Dong J, Yi H, Bai J, Gong J, Sun C, Zhu M, Wu T, Hu Z, Lin D, Shen H, Chen F#. A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility. Carcinogenesis. 2014 Jul;35(7):1528-35.

  30. Ding X, Wang M, Chu H, Chu M, Tong N, Wen Y, Wu D, Han B, Bai Z, Chen W, Yuan J, Wu T, Hu Z, Zhang Z, Shen H. Global gene expression profiling of human bronchial epithelial cells exposed to airborne fine particulate matter collected from Wuhan, China. Toxicol Lett. 2014 Apr 21;228(1):25-33.

  31. Zhang R, Zhao Y, Chu M, Wu C, Jin G, Dai J, Wang C, Hu L, Gou J, Qian C, Bai J, Wu T, Hu Z, Lin D, Shen H, Chen F. Pathway analysis for genome-wide association study of lung cancer in Han Chinese population.PLoS One. 2013;8(3):e57763.

  32. Zhang R, Zhao Y, Chu M, Mehta A, Wei Y, Liu Y, Xun P, Bai J, Yu H, Su L, Zhang H, Hu Z, Shen H, Chen F, Christiani DC. A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure.PLoS One. 2013;8(3):e59035.

  33. Wang C, Xu Z, Jin G, Hu Z, Dai J, Ma H, Jiang Y, Hu L, Chu M, Cao S, Shen H. Genome-wide analysis of runs of homozygosity identifies new susceptibility regions of lung cancer in Han Chinese.J Biomed Res. 2013 May;27(3):208-14

  34. Hu Z, Liu Y, Zhai X, Dai J, Jin G, Wang L, Zhu L, Yang Y, Liu J, Chu M, Wen J, Xie K, Du G, Wang Q, Zhou Y, Cao M, Liu L, He Y, Wang Y, Zhou G, Jia W, Lu J, Li S, Liu J, Yang H, Shi Y, Zhou W, Shen H. New loci associated with chronic hepatitis B virus infection in Han Chinese.Nat Genet. 2013 Dec;45(12):1499-503.

  35. Dai H, Zhao Y, Qian C, Cai M, Zhang R, Chu M, Dai J, Hu Z, Shen H, Chen F. Weighted SNP set analysis in genome-wide association study.PLoS One. 2013 Sep 30;8(9):e75897.

  36. Yuan Z, Yuan H, Ma H, Chu M, Wang Y, Hu Z, Shen H, Chen N Genetic variants at 10q23 are associated with risk of head and neck cancer in a Chinese population.Oral Oncol. 2013 Apr;49(4):332-5.

  37. Dong J, Jin G, Wu C, Guo H, Zhou B, Lv J, Lu D, Shi Y, Shu Y, Xu L, Chu M, Wang C, Zhang R, Dai J, Jiang Y, Yu D, Ma H, Zhao X, Yin Z, Yang L, Li Z, Deng Q, Cao S, Qin Z, Gong J, Sun C, Wang J, Wu W, Zhou G, Chen H, Guan P, Chen Y, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Liu J, Amos CI, Chen F, Tan W, Jin L, Wu T, Hu Z, Lin D, Shen H. Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese.PLoS Genet. 2013;9(1):e1003190.

  38. Deng Q, Guo H, Dai J, Yang L, Wu C, Wang Q, Hu Z, Yang M, Liu L, Yu D, Hu D, Hong X, Qiu F, Yang H, Wang T, Tan W, Chu M, Feng J, Teng K, Gong J, Sun C, Hu X, Zhang K, Lu J, Lin D, Shen H, Wu T. Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations.Carcinogenesis. 2013 Sep;34(9):2010-6.

  39. Cai M, Dai H, Qiu Y, Zhao Y, Zhang R, Chu M, Dai J, Hu Z, Shen H, Chen F. SNP set association analysis for genome-wide association studies.PLoS One. 2013 May 3;8(5):e62495.

  40. Shi Y, Li L, Hu Z, Li S, Wang S, Liu J, Wu C, He L, Zhou J, Li Z, Hu T, Chen Y, Jia Y, Wang S, Wu L, Cheng X, Yang Z, Yang R, Li X, Huang K, Zhang Q, Zhou H, Tang F, Chen Z, Shen J, Jiang J, Ding H, Xing H, Zhang S, Qu P, Song X, Lin Z, Deng D, Xi L, Lv W, Han X, Tao G, Yan L, Han Z, Li Z, Miao X, Pan S, Shen Y, Wang H, Liu D, Gong E, Li Z, Zhou L, Luan X, Wang C, Song Q, Wu S, Xu H, Shen J, Qiang F, Ma G, Liu L, Chen X, Liu J, Wu J, Shen Y, Wen Y, Chu M, Yu J, Hu X, Fan Y, He H, Jiang Y, Lei Z, Liu C, Chen J, Zhang Y, Yi C, Chen S, Li W, Wang D, Wang Z, Di W, Shen K, Lin D, Shen H, Feng Y, Xie X, Ma D. A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.Nat Genet. 2013 Aug;45(8):918-22.

  41. Hu L, Zhai X, Liu J, Chu M, Pan S, Jiang J, Zhang Y, Wang H, Chen J, Shen H, Hu Z. Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.Hepatology. 2012 May;55(5):1426-31.

  42. Dong J, Hu Z, Wu C, Guo H, Zhou B, Lv J, Lu D, Chen K, Shi Y, Chu M, Wang C, Zhang R, Dai J, Jiang Y, Cao S, Qin Z, Yu D, Ma H, Jin G, Gong J, Sun C, Zhao X, Yin Z, Yang L, Li Z, Deng Q, Wang J, Wu W, Zheng H, Zhou G, Chen H, Guan P, Peng Z, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Amos CI, Chen F, Tan W, Jin L, Wu T, Lin D, Shen H. Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population.Nat Genet. 2012 Jul 15;44(8):895-9.

  43. Li S, Qian J, Yang Y, Zhao W, Dai J, Bei JX, Foo JN, McLaren PJ, Li Z, Yang J, Shen F, Liu L, Yang J, Li S, Pan S, Wang Y, Li W, Zhai X, Zhou B, Shi L, Chen X, Chu M, Yan Y, Wang J, Cheng S, Shen J, Jia W, Liu J, Yang J, Wen Z, Li A, Zhang Y, Zhang G, Luo X, Qin H, Chen M, Wang H, Jin L, Lin D, Shen H, He L, de Bakker PI, Wang H, Zeng YX, Wu M, Hu Z, Shi Y, Liu J, Zhou W. GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers.PLoS Genet. 2012;8(7):e1002791.

  44. Hu L, Wu C, Zhao X, Heist R, Su L, Zhao Y, Han B, Cao S, Chu M, Dai J, Dong J, Shu Y, Xu L, Chen Y, Wang Y, Lu F, Jiang Y, Yu D, Chen H, Tan W, Ma H, Chen J, Jin G, Wu T, Lu D, Christiani DC, Lin D, Hu Z, Shen H. Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.Clin Cancer Res. 2012 Oct 1;18(19):5507-14.

  45. Jin G, Ma H, Wu C, Dai J, Zhang R, Shi Y, Lu J, Miao X, Wang M, Zhou Y, Chen J, Li H, Pan S,Chu M, Lu F, Yu D, Jiang Y, Dong J, Hu L, Chen Y, Xu L, Shu Y, Pan S, Tan W, Zhou B, Lu D, Wu T, Zhang Z, Chen F, Wang X, Hu Z, Lin D, Shen H. Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.Am J Hum Genet. 2012 Nov 2;91(5):928-34.

  46. Lan Q, Hsiung CA, Matsuo K, Hong YC, Seow A, Wang Z, Hosgood HD 3rd, Chen K, Wang JC, Chatterjee N, Hu W, Wong MP, Zheng W, Caporaso N, Park JY, Chen CJ, Kim YH, Kim YT, Landi MT, Shen H, Lawrence C, Burdett L, Yeager M, Yuenger J, Jacobs KB, Chang IS, Mitsudomi T, Kim HN, Chang GC, Bassig BA, Tucker M, Wei F, Yin Z, Wu C, An SJ, Qian B, Lee VH, Lu D, Liu J, Jeon HS, Hsiao CF, Sung JS, Kim JH, Gao YT, Tsai YH, Jung YJ, Guo H, Hu Z, Hutchinson A, Wang WC, Klein R, Chung CC, Oh IJ, Chen KY, Berndt SI, He X, Wu W, Chang J, Zhang XC, Huang MS, Zheng H, Wang J, Zhao X, Li Y, Choi JE, Su WC, Park KH, Sung SW, Shu XO, Chen YM, Liu L, Kang CH, Hu L, Chen CH, Pao W, Kim YC, Yang TY, Xu J, Guan P, Tan W, Su J, Wang CL, Li H, Sihoe AD, Zhao Z, Chen Y, Choi YY, Hung JY, Kim JS, Yoon HI, Cai Q, Lin CC, Park IK, Xu P, Dong J, Kim C, He Q, Perng RP, Kohno T, Kweon SS, Chen CY, Vermeulen R, Wu J, Lim WY, Chen KC, Chow WH, Ji BT, Chan JK, Chu M, Li YJ, Yokota J, Li J, Chen H, Xiang YB, Yu CJ, Kunitoh H, Wu G, Jin L, Lo YL, Shiraishi K, Chen YH, Lin HC, Wu T, Wu YL, Yang PC, Zhou B, Shin MH, Fraumeni JF Jr, Lin D, Chanock SJ, Rothman N. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.Nat Genet. 2012 Dec;44(12):1330-5.

  47. Hu Z, Wu C, Shi Y, Guo H, Zhao X, Yin Z, Yang L, Dai J, Hu L, Tan W, Li Z, Deng Q, Wang J, Wu W, Jin G, Jiang Y, Yu D, Zhou G, Chen H, Guan P, Chen Y, Shu Y, Xu L, Liu X, Liu L, Xu P, Han B, Bai C, Zhao Y, Zhang H, Yan Y, Ma H, Chen J, Chu M, Lu F, Zhang Z, Chen F, Wang X, Jin L, Lu J, Zhou B, Lu D, Wu T, Lin D, Shen H. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese.Nat Genet. 2011 Jul 3;43(8):792-6.

  48. Shi Y, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, Zhang H, Hu L, Jiang Y, Li Z, Chu M, Ma H, Chen J, Jin G, Tan W, Wu T, Zhang Z, Lin D, Shen H. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.Nat Genet. 2011 Oct 30;43(12):1215-8.




科研项目：

均以项目主持人身份主持以下项目：

  1. 国家自然科学基金青年项目：CPM基因区域遗传变异与尘肺病易感性的精细定位研究

  2. 江苏省自然科学基金面上项目：环状RNA作为ceRNA对矽肺纤维化进程影响及其机制研究

  3. 江苏省高校自然科学研究面上项目：CPM基因遗传变异与尘肺病易感性的精细定位研究

  4. 南通市科技计划项目：染色体12q15区域遗传变异与尘肺病易感性的分子流行病学研究

  5. 南通市科技计划项目：长链非编码RNA及其遗传变异与膝骨关节炎易感性的分子流行病学研究


获得奖项：

  1. 江苏省医学新技术引进一等奖（排名第3），新型靶标miR-SNPs在非小细胞肺癌个体化诊治中的筛选与临床应用，2017.09

  2. 南通市科技进步二等奖（排名第2），肥胖相关基因与骨关节炎发生和进展的相关性研究，2018.04


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