吴启运    研究员

医学硕士、研究员、硕士生导师;1985年毕业于镇江医学院医学检验专业;1992年研究生毕业于上海医科大学威尼斯欢乐娱人v675，医学硕士。现任威尼斯欢乐娱人v675科学技术处处长。主持国家级项目2项，发表SCI论文21篇。

招生方向：

劳动与环境卫生学、食品与营养卫生学

代表论文：

（1）Man, Jiao#; Kaizhi, Yin#; Tao, Zhang; Changyue, Wu; Yan, Zhang; Xinyuan, Zhao*; Qiyun, Wu*，Effect of the SSeCKS-TRAF6 interaction on gastrodin-mediated protection against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced astrocyte activation and neuronal death，Chemosphere, 2019, 226: 678-686.  SCIE。

（2）Wu Changyue; Yin Kaizhi; Zhang Yan; Jiao Man; Zhao Xinyuan*; Wu Qiyun*，2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotes Proliferation of Astrocyte Cells via the Akt/STAT3/Cyclin D1 Pathway

，Biomedical and Environmental Sciences, 2019, 32(4): 281-290.  SCIE。

（3）Ge, Jianbin#; Wang, Cheng#; Nie, Xiaoke; Yang, Jianbin; Lu, Hongjian; Song, Xinjian; Su, Kai; Li, Ting; Han, Jingling; Zhang, Yan; Mao, Jiamin; Gu, Yiyang; Zhao, Jianya; Jiang, Shengyang; Wu, Qiyun*，ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure，Environmental Toxicology and Pharmacology, 2016, 46: 9-16. SCI.

（4）Zhao, Jianya#; Zhang, Yan#; Zhao, Jianmei; Wang, Cheng; Mao, Jiamin; Li, Ting; Wang, Xiaoke; Nie, Xiaoke; Jiang, Shengyang; Wu, Qiyun*，2,3,7,8-tetrachlorodibenzo-p-dioxin exposure influence the expression of glutamate transporter GLT-1 in C6 glioma cells via the Ca2+/protein kinase C pathway，Journal of Applied Toxicology, 2016, 36(11): 1409-1417.  SCIE。

（5）Chen, Gang#; Mao, Jiamin#; Zhao, Jianmei; Zhang, Yan; Li, Ting; Wang, Cheng; Xu, Lingfei; Hu, Qiaoyun; Wang, Xiaoke; Jiang, Shengyang; Nie, Xiaoke; Wu, Qiyun*，Arsenic trioxide mediates HAPI microglia inflammatory response and the secretion of inflammatory cytokine IL-6 via Akt/NF-kappaB signaling pathway.，Regul Toxicol Pharmacol, 2016, 81: 480-488.  SCIE, SSCI。

（6）Yang, Jianbin; Wang, Cheng; Nie, Xiaoke; Shi, Shangshi; Xiao, Jing; Ma, Xia; Dong, Xuan; Zhang, Yan; Han, Jingling; Li, Ting; Mao, Jiamin; Liu, Xinhang; Zhao, Jianya*; Wu, Qiyun*，Perfluorooctane sulfonate mediates microglial activation and secretion of TNF-alpha through Ca2+-dependent PKC-NF-kappa B signaling，International Immunopharmacology, 2015, 28(1): 52-60. SCI。

（7）Wan, Chunhua#; Zhang, Yang#; Jiang, Junkang; Jiang, Shengyang; Nie, Xiaoke; Li, Aihong; Guo, Aisong; Wu, Qiyun*，Critical Role of TAK1-Dependent Nuclear Factor-kappa B Signaling in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced Astrocyte Activation and Subsequent Neuronal Death，Neurochemical Research, 2015, 40(6): 1220-1231. SCI.

（8）Wang, Cheng; Nie, Xiaoke; Zhang, Yan; Li, Ting; Mao, Jiamin; Liu, Xinhang; Gu, Yiyang; Shi, Jiyun; Xiao, Jing; Wan, Chunhua; Wu, Qiyun*， Reactive oxygen species mediate nitric oxide production through ERK/JNK MAPK signaling in HAPI microglia after PFOS exposure，Toxicology and Applied Pharmacology, 2015, 288(2): 143-151.  SCIE.

（9）Zhang, Yang#; Nie, Xiaoke#; Tao, Tao; Qian, Wenbo; Jiang, Shengyang; Jiang, Junkang; Li, Aihong; Guo, Aisong; Xu, Guangfei*; Wu, Qiyun*，2,3,7,8-tetrachlorodibenzo-p-dioxin promotes astrocyte activation and the secretion of tumor necrosis factor-a via PKC/SSeCKs-dependent mechanisms，Journal of Neurochemistry, 2014, 129(5): 839-849.  SCIE.

（10）Duan, Zhiqing; Zhao, Jianya; Fan, Xikang; Tang, Cuiying; Liang, Lingwei; Nie, Xiaoke; Liu, Jiao; Wu, Qiyun*; Xu, Guangfei*，The PERK-eIF2 alpha signaling pathway is involved in TCDD-induced ER stress in PC12 cells，NeuroToxicology, 2014, 44: 149-159. SCI.

Xu, Wei#; Cao, Maohong#; Zheng, Heyi; Tan, Xiang; Li, Lei; Cui, Gang; Xu, Jian; Cao, Jianhua; Ke, Kaifu*; Wu, Qiyun*，Upregulation of SYF2 Is Associated With Neuronal Apoptosis Caused by Reactive Astrogliosis to Neuroinflammation，Journal of Neuroscience Research, 2014, 92(3): 318-328. SCI.

（11）Cao, Maohong; Xu, Wei; Yu, Jian; Zheng, Heyi; Tan, Xiang; Li, Lei; Rui, Ying; Xu, Guangfei; Cui, Gang; Xu, Jian; Cao, Jianhua; Tao, Tao; Ke, Kaifu*; Wu, Qiyun*，Up-regulation of SGTB is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide，Journal of Molecular Histology, 2013, 44(5): 507-518.  SCIE。

科研项目：

（1）TCDD经SSeCKS/TRAF6通路诱导星形胶质细胞激活致神经毒性的机制研究，国家自然科学基金，21477058，87.00 万元，2015.01-2018.12，主持，已结题。

（2）肝癌高发和低发区域影响因素的综合分析，国家重点研发专项，2019FY101103，60万元，2020.01-2022.12，主持，在研。