姓名：万春华     

职称：教授 博士生导师

电话：051385012911

个人简介

万春华，江西南昌人，2011年北京协和医学院生物化学与分子生物学专业博士毕业。目前主要从事消化系统疾病和代谢异常的机制研究，主要利用分子生物学、细胞生物学和实验动物学等研究手段研究消化系统器官如肝脏、胰腺和肠道的代谢异常和慢性疾病发生的分子机制。已主持或正在主持多个国家自然科学基金项目、以主要作者在Science Advances、Oncogene、Cancer letters、Cells，Cancers和Toxicology等杂志发表SCI论文40余篇，总影响因子100余，总引用次数在1600以上。授权发明专利3项，获江苏省“333高层次人才培养对象”和南通市“226高层次人才培养工程”培养对象等人才项目，具有良好的学术造诣。

专业研究领域

消化系统代谢性疾病发生

消化系统肿瘤和发生机制

应激性通路在消化系统器官疾病发生中的功能

学术论文（选填）

1.Wan C, Mahara S, Sun C, Doan A, Chua HK, Xu D, Bian J, Li Y, Zhu D, Sooraj D, Cierpicki T, Grembecka J, Firestein R. Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer. Science Advances. 2021 May 19;7(21):eabf2567 (PMID: 34138730)

2.Sooraj D, Sun C, Doan A, Garama DJ, Dannappel MV, Zhu D, Chua HK, Mahara S, Wan Hassan WA, Tay YK, Guanizo A, Croagh D, Prodanovic Z, Gough DJ, Wan C, Firestein R. MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase. Mol Cell. 2022 Jan 6;82(1):123-139.e7 (PMID: 34910943)

3.Wan C, Yan X, Hu B, Zhang X. Emerging Roles of the Nervous System in Gastrointestinal Cancer Development. Cancers (Basel). 2022 Jul 30;14(15):3722 (PMID: 35954387)

4.Wan C, Wu M, Zhang S, Chen Y, Lu C. α7nAChR-mediated recruitment of PP1γ promotes TRAF6/NF-κB cascade to facilitate the progression of Hepatocellular Carcinoma. Molecular Carcinogenesis. 2018 Nov;57(11):1626-1639 (PMID: 30074282)

5.Wan C, Gong C, Zhang H, Hua L, Li X, Chen X, Chen Y, Ding X, He S, Cao W, Wang Y, Fan S, Xiao Y, Zhou G, Shen A. β2-adrenergic receptor signaling promotes pancreatic ductal adenocarcinoma (PDAC) progression through facilitating PCBP2-dependent c-myc expression. Cancer Letters. 2016 Apr 1;373(1):67-76 (PMID: 26803058)

6.Hu B, Hua L, Ni W, Wu M, Yan D, Chen Y, Lu C, Chen B, Wan C. Nucleostemin/GNL3 promotes nucleolar polyubiquitylation of p27kip1 to drive hepatocellular carcinoma progression. Cancer Letters. 2017 Mar 1;388:220-229 (PMID: 27998760) (Corresponding author)

7.Wan C, Hou S, Ni R, Lv L, Ding Z, Huang X, Hang Q, He S, Wang Y, Cheng C, Gu XX, Xu G, Shen A. MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability. Oncogene. 2015 Jan 8;34(2):237-45 (PMID: 24336329).

8.Wan C, Fu J, Wang Y, Miao S, Song W, Wang L. Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis. PLoS One. 2012;7(5):e37452 (PMID: 22624035)

主要科研项目