个人简介：  

韩毓，医学博士，毕业于苏州大学医学部基础医学与生命科学学院。现任教于威尼斯欢乐娱人v675职业医学与环境毒理学系，副教授，硕士研究生导师，江苏省毒理学会第三届理事会理事，中国毒理学会毒理学教育第二届专业委员会委员。近年来主要从事免疫毒理学相关方面的研究工作，主持完成国家自然科学基金青年科学基金项目一项、江苏省自然科学基金青年科学基金项目一项、南通市科技计划项目两项，并在SCI收录期刊与国内核心期刊发表学术论文十余篇。

招生方向：职业医学与环境毒理学

代表论文：

1. Yu Han*1, Xiangjun Yu1, Ying Lu1, Yi Shen, Xiaoying Wang, Haiyan Wei, Kaihua Ni, Jianhua Qu*, Gang Chen*. Di-(2-ethylhexyl) phthalate aggravates fine particulate matter-induced asthma in weanling mice due to T follicular helper cell-dependent response. Toxicology, 2023, 484:153406. 

2. Yilun Liang, Yun Qian, Jing Tang, Chenjuan Yao, Shali Yu, Jianhua Qu, Haiyan Wei, Gang Chen*, Yu Han*. Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIMEL to attenuate apoptosis in BEAS-2B cells. Chemico-Biological Interactions, 2023, 369:110304.  

3. Jiaming Yuan1, Chenjuan Yao1, Jing Tang, Yingqi Liu, Chunyan Huang, Shali Yu, Haiyan Wei, Yu Han*, Gang Chen*. Enhanced GRP78 protein expression via the IRE1α/ASK1/p38 MAPK pathway during As2O3-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology, 2021, 462:152962.

4. Jianhua Qu*1, Yu Han1, Ziyan Zhao1, Yuan Wu, Ying Lu, Gang Chen, Junkang Jiang, Lianglin Qiu, Aihua Gu**, Xinru Wang b**. Perfluorooctane sulfonate interferes with non-genomic estrogen receptor signaling pathway, inhibits ERK1/2 activation and induces apoptosis in mouse spermatocyte-derived cells. Toxicology, 2021, 460:152871.

5. Yu Han, Xiaoying Wang, Xiaoxiao Pang, Mangze Hu, Ying Lu, Jianhua Qu, Gang Chen*. Di-(2-ethylhexyl)-phthalate interferes with T-follicular helper cell differentiation and cytokine secretion through signaling lymphocytic activation molecule family member-1. Journal of Immunotoxicology, 2019, 16(1):155-163.

6. Xinyuan Zhao*1, Yifan Wu1, Jinlong Li, Dongyu Li, Yang Jin, Piaoyu Zhu, Yingqi Liu, Yin Zhuang, Shali Yu, Weiming Cao, Haiyan Wei, Xiaoke Wang, Yu Han*, Gang Chen*. JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation. Toxicology, 2019, 423:42-53.

7. Changyue Wu, Yifan Wu, Yang Jin, Piaoyu Zhu, Weiwei Shi, Jinlong Li, Qiyun Wu, Qinglin Zhang*, Yu Han*, Xinyuan Zhao*. Endosomal/lysosomal location of organically modified silica nanoparticles following caveolae-mediated endocytosis. RSC Advances, 2019, 9:13855-13862.

8. Han Y, Wang X, Chen G, Xu G, Liu X, Zhu W, Hu P, Zhang Y, Zhu C, Miao J*. Di-(2-ethylhexyl) phthalate adjuvantly induces imbalanced humoral immunity in ovalbumin-sensitized BALB/c mice ascribing to T follicular helper cells hyperfunction. Toxicology, 2014, 324:88-97.

9. Han Y#, Zhou X#, Ji Y, Shen A, Sun X, Hu Y, Wu Q, Wang X*. Expression of β-1,4-galactosyltransferase-I affects cellular adhesion in human peripheral blood CD4+ T cells. Cellular Immunology, 2010, 262(1):11-17.

科研项目：  

1. 国家自然科学基金青年科学基金项目（21607082），滤泡辅助性T细胞在DEHP与PM2.5联合暴露诱导哮喘中的作用及机制研究，2017.01-2019.12，主持完成；

2. 江苏省自然科学基金青年科学基金项目（BK20160414），DEHP与PM2.5联合暴露诱导生长期小鼠哮喘的作用及其机制研究，2016.07-2019.06，主持完成；

3. 南通市科技计划项目（JC2020022），基于辅助性T细胞分化可塑性研究DEHP与PM2.5联合暴露诱导哮喘的作用机制，2020.10-2022.09，主持在研。