个人简介：

 万春华，博士，教授，博士生导师。江苏省“333高层次人才培养工程”和南通市“226高层次人才培养工程”培养对象，国家自然科学基金通讯评审专家。主要机体营养代谢及代谢性疾病发生发展的机制研究。主持国家自然科学基金面上项目2项和青年基金1项、以及江苏省教育厅面上项目和南通市科技项目多项。在国内外高水平研究期刊发表研究性论文60余篇，其中包括以主要作者在Science Advances、Oncogene、Cancer letters、Cells和Toxicology等杂志发表论文多篇，总影响因子超过180分，总引用超过2000次。授权发明专利5项，与国内外高水平研究机构存在密切合作。

招生方向：代谢性疾病的分子发生机制、消化系统疾病的病例分子机制

代表论文：

1. Wan C, Yan X, Hu B, Zhang X. Emerging Roles of the Nervous System in Gastrointestinal Cancer Development. Cancers (Basel). 2022 Jul 30;14(15):3722.

2. Wan C, Gu T, Ling J, Qin Y, Luo J, Sun L, Hua L, Zhao J, Jiang S. Perfluorooctane sulfonate aggravates CCl4-induced hepatic fibrosis via HMGB1/TLR4/Smad signaling. Environmental Toxicology. 2022 May;37(5):983-994.

3. Qin Y, Gu T, Ling J, Luo J, Zhao J, Hu B, Hua L, Wan C, Jiang S. PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome-mediated hepatocyte pyroptosis. Journal of Applied Toxicology. 2022 May;42(5):806-817.

4. Wan C, Mahara S, Sun C, Doan A, Chua HK, Xu D, Bian J, Li Y, Zhu D, Sooraj D, Cierpicki T, Grembecka J, Firestein R. Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer. Science Advances. 2021 May 19;7(21):eabf2567.

5. Jiang Y, Gu L, Zhang Z, Zhao J, Wan C. Severe Zinc Deficiency Causes the Loss and Apoptosis of Olfactory Ensheathing Cells (OECs) and Olfactory Deficit. Journal of Molecular Neuroscience. 2021 Apr;71(4):869-878.

6. Sun L, Wang X, Gu T, Hu B, Luo J, Qin Y, Wan C. Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes. Toxicology. 2020 Aug;441:152502.

7. Sun P, Nie X, Chen X, Yin L, Luo J, Sun L, Wan C, Jiang S. Nrf2 Signaling Elicits a Neuroprotective Role Against PFOS-mediated Oxidative Damage and Apoptosis. Neurochemical Research. 2018 Dec;43(12):2446-2459.

8. Wan C, Wu M, Zhang S, Chen Y, Lu C. α7nAChR-mediated recruitment of PP1γ promotes TRAF6/NF-κB cascade to facilitate the progression of Hepatocellular Carcinoma. Molecular Carcinogenesis. 2018 Nov;57(11):1626-1639.

9. Hu B, Hua L, Ni W, Wu M, Yan D, Chen Y, Lu C, Chen B, Wan C. Nucleostemin/GNL3 promotes nucleolar polyubiquitylation of p27kip1 to drive hepatocellular carcinoma progression. Cancer Letters. 2017 Mar 1;388:220-229.

10. Wan C, Hou S, Ni R, Lv L, Ding Z, Huang X, Hang Q, He S, Wang Y, Cheng C, Gu XX, Xu G, Shen A. MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability. Oncogene. 2015 Jan 8;34(2):237-45.

科研项目：

1. CRISPR-Cas9全基因组筛选分析肝癌中NF-κB通路调控机制（81972279），国家自然科学基金面上项目，2020.01-2023.12，55.0万元，负责人, 正在进行；

2. 慢性精神应激通过α7nAchR-PP1γ促进肝细胞肝癌发生发展的机制研究（81672388），国家自然科学基金面上项目，2017.01-2020.12，57.0万元，负责人, 已结题。