个人简介:
朱晓霞,农学博士,副教授,硕士生导师。2007年毕业于南京农业大学植物病理专业,主要从事新型免疫分析技术和传感器的构建及应用。2012年入选南通市“江海英才”计划,主持国家自然科学基金青年、江苏省高校自然科学基金面上、南通市科技计划等项目。以第一作者和通讯作者在Anal Chem、JournalofAgriculturalandFoodChemistry、Sensors and Actuators B: Chemical等杂志发表SCI论文20余篇,其中中科院一区5篇,授权国家发明专利两项。
招生方向:公共卫生
研究方向简介:
主要从事新型免疫分析技术的研究,致力于高灵敏度、痕量物质的快速分析方法的建立及应用基础研究,包括单克隆抗体、纳米抗体、适配体等免疫检测核心试剂的研制;传感器的构建及应用,实现现场即时多组分同时监测。
代表论文:
1. Yafang Chen, Anan Xu, Jiajia Li, Xiaoxia Zhu*, Meiyin Zou, Shan Liu. J Pharmaceutical and biomedical analysis. 2023, Highly sensitive paper-based immunoassay: combining nanomaterials modified cellulose with covalent and oriented immobilization of antibody. 231, 115389.
2. Xiaoxia Zhu, Xiaye Miao, Xinyue Qin, Xiaohong Zhu. J. Pharmaceutical and biomedical analysis, 2019, Design of immunogens: The effect of bifunctional chelator on immunological response to chelated copper. 174, 263-269.
3. Xiaoxia Zhu, Shidan Xiong, Xiao Zhang,Xin Tong, Shan Kong. Sensors and Actuators B: Chemical, 2018, Improving paper-based ELISA performance through covalent immobilization of antibodies. 255: 598-604.
4. Xiaoxia Zhu, Yueying Guo, Zhenyun Huang, Shumei Yang. Clin Lab. 2014, Rheumatoid factor interference of α-fetoprotein evaluations in human serum by ELISA.60: 1795-1800.
5. QiWang,Xiuying Shi,Xiaoxia Zhu,MEhlers,Junchen Wu, C Schmuck. Chem Commun. 2014, Afluorescentlight-upprobeasaninhibitorofintracellularbeta-tryptase.50(46):6120-6122.
6. Xiaoxia Zhu,Qi Wang,Xiuying Shi,Fengquan Liu,Liming Wang,Huiming Wang.Anal Methods. 2013, DevelopmentandanalyticalvalidationofanEnzyme-LinkedImmunosorbentAssay (ELISA)forthe detection ofcopper in humanhair andserum samples.5:2578-2583.
7. Fengquan Liu, Yang Lou,Xiuying Shi,Huiming Wang, Xiaoxia Zhu*. J. Immunol Methods. 2013, Preparationandcharacterizationofmonoclonalantibodyspecificforcopper-chelatecomplex.387: 228-236.
8. Xiaoxia Zhu,A Kriegel,C Boustany,andD.A. Blake.AnalChem. 2011, Single-ChainVariableFragment(scFv)AntibodiesOptimizedforEnvironmentalAnalysisof Uranium. 83: 3717-3724.
9. Xiaoxia Zhu, B.Ban, Xiao Yang, SShevkoplas, D.A.Blake.DevelopmentofanImmunochromatographicStripforRapid,Instrument-Free,On-Site Detection ofUranium. TheNewUraniumMining Boom. Springer. 2011, 499-504.
10. DA. Blake,Xiaoxia Zhu,B Ban.EnvironmentalAnalysisofUraniumwithRecombinantAntibodies.TheNewUraniumMiningBoom.Springer, 2011, 467-476.
11. XiaoxiaZhu, BaishiHu,YangLou,LinaXu,FengliYang,HainiYu,DianeA.Blake,andFengquanLiu*,CharacterizationofMonoclonal AntibodiesforLead-ChelateComplexes:ApplicationsinAntibody-BasedAssays,JournalofAgriculturalandFoodChemistry.2007,55: 4993-4998.
12. XiaoxiaZhu,LinaXu,YangLou,HainiYu,XiaLi,DianeABlake,FengquanLiu.PreparationofSpecificMonoclonalAntibodies(MAbs) against HeavyMetals: MAbs that RecognizeChelated CadmiumIons.Journal of Agriculturaland Food Chemistry, 2007,55:7648-7653.
13. YangLou,XiaoxiaZhu,FengliYang,FengquanLiu.ProductionofaSpecificMonoclonalAntibodyAgainstMercury-chelatecomplexes and its application in antibody-based assays.Foodand AgriImmun, 2009, 20:23-33.
14. FengliYang,Xiaoxia,Zhu,BaishiHu,Lina,Xu,YangLou,FengquanLiu.Chinese HighTechnologyLetters, 2008, PreparationandCharacterizaitonofSpecificMonoclonal Anitbodies of Mercury. 5:531-536.
15. QiZhang,TiejunLi,XiaoxiaZhu,LinaXu,FengquanLiu,BaishiHu,YinghuaJiang,BingCao.Agricultural Sciences in China,2007, ProducitonandCharacterizationof Polyclonal Antibodyforthe N-MethylcarbamateInsecticide Metolcarb. 6: 175-179.
16. 徐安安,陈亚芳,周诗梦,赵如良,朱晓霞*. 基于还原型半抗体构建新型冠状病毒检测的电化学免疫传感器,分析化学进展,2023,13(2),134-142.
17. 刘珊,朱晓霞*,缪夏晔. 纸基ELISA的应用及其研究进展。现代免疫学,2019,39(5):433-436.
18. 张家琴,朱晓霞*.电化学传感器及其在重金属检测中的应用。威尼斯欢乐娱人v675学报(自然科学版)2018,17(1):28-38.
19. 杨洪鹏,朱晓霞*.卵巢癌患者外周血T淋巴细胞的表达分析。 中国肿瘤临床与康复,2014,5:534-536.
科研项目:
1. 国家自然基金,21407083,基于酶蛋白再激活构筑重金属电化学免疫传感器的研究,2015.01-2017.12,24万元,结题,主持;
2. 南通市社会发展科技计划项目,MS12018011,纳米佐剂用于铜单克隆抗体制备及免疫效果研究,2018.06-2020.09,5万元,结题,主持;
3. 南通市社会发展科技计划项目,MS201501,基于量子点构建多种重金属同步定量免疫分析技术的研究,2016.01-2018.09,5万元,结题,主持;
4. 江苏省高校自然科学基金,14KJB33005,基于酶蛋白再激活用于重金属电化学免疫传感器的研究,2014.07-2016.12,3万元,结题,主持;
5. 重金属铜快速检测技术研究,HS2011011,南通市科技项目,2011.06-2013.06,3万元,结题,主持。